Similar to its UNSC and Covenant counterparts, the Incineration Cannon is best used when shooting the ground in the close proximity of an enemy. The wide spread of the weapon's projectiles increase the effectiveness of this technique even more so than with the weapon's counterparts.
In encounters with M808 Scorpion and Type-26 Wraith tanks, players can inflict maximum damage by shooting at the lower part of the tank. If that shot strikes the tank, it will completely destroy it in one hit, because when the main particle explodes, the four remaining ones will go up and explode under the tank, damaging all the parts.
Of all the heavy weapons, the Incineration Cannon is the most effective against the Mark IX Mantis ADS. A single direct hit on the Mantis's cockpit will destroy it; all other heavy weapons require at least two hits, one to remove the shields and one to finish the vehicle off. However, since the Incineration Cannon uses a multiple-projectile round, the Mantis will lose its shields to the first set of projectiles while the secondary ones finish it off.
The Incineration Cannon makes an effective long-range power weapon; because, unlike its counterparts, the projectiles of the weapons suffer no gravitational drop over long distances, its quite possible to kill an enemy from across the map with the weapon. This is particularly useful on maps with long sight lines, or while playing Husky Raid in Action Sack.
A Damage Boosted Incineration Cannon is the most powerful weapon in the game, hands down. Should you find yourself in such a situation, engage any and all targets without hesitation.
The new Incineration Cannon now features two fire modes; one that operates as a two-shot mortar, the other a charged shot similar to its original firing mode, albeit without any secondary explosions.
The mortar is good for indirect fire and for single-target engagement at close range. It can be fired twice in quick succession before overheating, and two volleys are usually enough to kill an enemy.
The charged shot is excellent for engaging targets at range (since it has unlimited range, a perfectly straight flight path, and a large hitbox and splash damage area that will one-shot any enemy within it), groups of enemies, vehicles, and clearing out tight corridors. It consumes a fourth of the weapon's battery, however.
Unlike in Halo 4, the Incineration Cannon is considerably more common in the Halo 5: Guardians campaign. The Incineration Cannon is first found in Glassed, but can be missed if the player chooses to destroy the door's power generator and open the door earlier without spawning the Knight Commanders.
It later appears in every subsequent level where Prometheans appear as enemies.
The Incineration Cannon, with its charged shot, can kill a campaign character and make them unrevivable until they respawn.
Warzone and Arena feature two variants, both with 25% larger battery capacity:
River of Light: an improved Incineration Cannon which replaces the large cluster charge shot with a rapid-fire stream of normal pulses and has a faster rate of fire. It is most effective at putting damage onto a big target (e.g. a boss or vehicle) very quickly.
Heartseeker: an advanced Incineration Cannon that fires slower-moving tracking energy charges and has 30% greater range with a trade-off of a tighter arcing trajectory. It is most effective when used as an anti-infantry weapon, as one pull of the trigger with a red reticle lock is enough to kill an enemy who doesn't have an Overshield. However, it is still useful for dealing with aerial units due to its strong tracking, which can hit even evading Banshees and Phaetons, if the environment is not to be considered.