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'''Smoothers''' is the name given by the [[Gamma Company]] [[SPARTAN-III program|Spartans]] to the drug cocktail that acts as a counteragent to the effects of mutagen 009762-OO.
'''Smoothers''' is the name given by the [[Gamma Company]] [[SPARTAN-III program|Spartans]] to the drug cocktail that acts as a counteragent to the effects of mutagen 009762-OO.
==Overview==
==Overview==
Smoothers are a cocktail of cyclodexione-4 and miso-olanzapine which act as a counteragent to the effects of mutagen 009762-OO, used in the [[Project CHRYSANTHEMUM|augmentation procecures]] of the [[SPARTAN-III program]].{{Ref/Novel|Id=LL123|LL|Page=123}} Without Smoothers, a Spartan will lose their strategic judgment and become more prone to impulsive, instinct-driven behavior.{{Ref/Novel|GoO|Page=340}}
Smoothers were a cocktail of cyclodexione-4 and miso-olanzapine which acted as a counteragent to the effects of mutagen 009762-OO.{{Ref/Novel|Id=LL123|LL|Page=123}} Without Smoothers, the Spartan will lose their strategic judgment and become more prone to impulsive, instinct-driven behavior.{{Ref/Novel|GoO|Page=340}}


There are several different types of "Smoother". The most common type used during combat operations is administered via a hypodermic injection and lasts approximately twelve hours, after which its effectiveness begins to steadily decrease. Several factors such as stress and fatigue can precipitate the mental unraveling process.{{Ref/Novel|Id=ll145|LL|Page=145-146}} Ash referred to the Smoother-deprived state as "Gamma-mode fury."{{Ref/Novel|Id=DW17|DW|Chapter=17}} The first symptoms, appearing within several hours after the Smoothers' effect wears off, include nervousness and irritability,{{Ref/Novel|LL|Page=182}}{{Ref/Novel|Id=ll214|LL|Page=214-215}} eventually followed by paranoia, fits of temper and physical outbursts.{{Ref/Reuse|ll145}} After well over a day without a Smoother injection,{{Ref/Reuse|ll214}} [[Mark-G313]] began having difficulties distinguishing friend from foe in the middle of a firefight, holding a combat knife to [[Nguyen|a Marine sergeant]]'s throat before being successfully convinced by Fred-104 that the Marine was an ally rather than an enemy infiltrator.{{Ref/Novel|Id=LL247|LL|Page=247}} Another, significantly more expensive type of Smoother is a subcutaneous insert with a longer-lasting effect. While they can only be changed out in a medical facility, they also cannot be lost or destroyed during a mission like the more commonly used kind.{{Ref/Novel|LL|Page=249}} While in a Smoother-deprived state, [[Ash-G099]] had to be dangled out of a Pelican by [[Alice-130]] in order to be brought back to his senses. Once Alice assured him that [[Mark-G313]] really was dead and allowed Ash to check, he calmed down completely. Seeing that Olivia was going to put everyone onboard in danger in her "Gamma-mode fury," Ash warned Alice not to use [[polypseudomorphine|polly-sue]] or sedatives on either of them as they wouldn't work and would only serve to make Ash and Olivia crazy.{{Ref/Reuse|DW17}}
There are several different types of "Smoother". The most common type used during combat operations is administered via a hypodermic injection and lasts approximately twelve hours, after which its effectiveness begins to steadily decrease. Several factors such as stress and fatigue can precipitate the mental unraveling process.{{Ref/Novel|Id=ll145|LL|Page=145-146}} Ash referred to the Smoother-deprived state as "Gamma-mode fury."{{Ref/Novel|Id=DW17|DW|Chapter=17}} The first symptoms, appearing within several hours after the Smoothers' effect wears off, include nervousness and irritability,{{Ref/Novel|LL|Page=182}}{{Ref/Novel|Id=ll214|LL|Page=214-215}} eventually followed by paranoia, fits of temper and physical outbursts.{{Ref/Reuse|ll145}} After well over a day without a Smoother injection,{{Ref/Reuse|ll214}} [[Mark-G313]] began having difficulties distinguishing friend from foe in the middle of a firefight, holding a combat knife to [[Nguyen|a Marine sergeant]]'s throat before being successfully convinced by Fred-104 that the Marine was an ally rather than an enemy infiltrator.{{Ref/Novel|Id=LL247|LL|Page=247}} Another, significantly more expensive type of Smoother is a subcutaneous insert with a longer-lasting effect. While they can only be changed out in a medical facility, they also cannot be lost or destroyed during a mission like the more commonly used kind.{{Ref/Novel|LL|Page=249}} While in a Smoother-deprived state, [[Ash-G099]] had to be dangled out of a Pelican by [[Alice-130]] in order to be brought back to his senses. Once Alice assured him that [[Mark-G313]] really was dead and allowed Ash to check, he calmed down completely. Seeing that Olivia was going to put everyone onboard in danger in her "Gamma-mode fury," Ash warned Alice not to use [[polypseudomorphine|polly-sue]] or sedatives on either of them as they wouldn't work and would only serve to make Ash and Olivia crazy.{{Ref/Reuse|DW17}}

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